Rome is a city in Oneida County, New York, United States, located in the central part of the state. The population was 33,725 at the 2010 census. Rome is one of two principal cities in the Utica–Rome Metropolitan Statistical Area, which lies in the "Leatherstocking Country" made famous by James Fenimore Cooper's Leatherstocking Tales, set in frontier days before the American Revolutionary War. Rome is in New York's 22nd congressional district.The city developed at an ancient portage site of Native Americans, including the historic Iroquois. It continued to be strategically important to Europeans who also used the main 18th and 19th-century waterways, based on the Mohawk and Hudson rivers, that connected New York City and the Atlantic seaboard to the Great Lakes. The original European settlements developed around fortifications erected in the 1750s to defend the waterway, in particular the British Fort Stanwix.